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1

Political Science and the Jews: A Review Essay on the Holocaust, the State of Israel, and the Comparative Analysis of Jewish Communities; The Jewish State: A Century Later.; Comparing Jewish Societies.; Rubber Bullets: Power and Conscience in Modern Israel.; Jews and the New American Scene.; Palestinian Citizens in an Ethnic Jewish State: Identities in Conflict.; The Order of Terror: The Concentration Camp.; The Founding Myths of Israel.;

Zuckerman, Alan S., Dowty, Alan, Endelman, Todd M., Ezrahi, Yaron, Lipset, Seymour Martin, Raab, Earl, Rouhana, Nadim N., Sofsky, Wolfgang, Templer, William, Sternhell, Zeev, Maisel, David

Journal:

American Political Science Review

Année:

1999

Langue:

english

Fichier:

PDF, 1.33 MB

english, 1999

2

Mineralogy, petrology and chemistry of lithic fragments from Luna 20 fines: origin of the cumulate ANT suite and its relationship to high-alumina and mare basalts

Martin Prinz, Eric Dowty, Klaus Keil, T.E Bunch

Journal:

Geochimica et Cosmochimica Acta

Année:

1973

Langue:

english

Fichier:

PDF, 2.37 MB

english, 1973

3

Discovery of a novel JAK3-selective inhibitor: Functional differentiation of JAK3-selective inhibition over pan-JAK or JAK1-selective inhibition

Telliez, Jean-Baptiste, Dowty, Martin E., Wang, Lu, Jussif, Jason, Lin, Tsung, Li, Li, Moy, Erick, Balbo, Paul, Li, Wei, Zhao, Yajuan, Crouse, Kimberly, Dickinson, Caitlyn, Symanowicz, Peter, Hegen, M

Journal:

ACS Chemical Biology

Année:

2016

Langue:

english

Fichier:

PDF, 1.62 MB

english, 2016

4

Design of a Janus Kinase 3 (JAK3) Specific Inhibitor 1-((2 S ,5 R )-5-((7 H -Pyrrolo[2,3- d ]pyrimidin-4-yl)amino)-2-methylpiperidin-1-yl)prop-2-en-1-one (PF-06651600) Allowing for the Interrogation of JAK3 Signaling in Humans

Thorarensen, Atli, Dowty, Martin E., Banker, Mary Ellen, Juba, Brian, Jussif, Jason, Lin, Tsung, Vincent, Fabien, Czerwinski, Robert M., Casimiro-Garcia, Agustin, Unwalla, Ray, Trujillo, John I., Lian

Journal:

Journal of Medicinal Chemistry

Année:

2017

Langue:

english

Fichier:

PDF, 1.58 MB

english, 2017

5

P11 - Expanding the phenotyping tool kit for glutathione S-transferases

Strelevitz, Timothy, Cerny, Matthew A., Dowty, Martin

Journal:

Drug Metabolism and Pharmacokinetics

Année:

2020

Fichier:

PDF, 47 KB

2020

6

The efficacy and cardiac evaluation of aminomethyl tetrahydronaphthalene ketopiperazines: A novel class of potent MCH-R1 antagonists

José L. Méndez-Andino, Anny-Odile Colson, Kenneth M. Meyers, Maria C. Mitchell, Karen Hodge, Jeremy M. Howard, Nicholas Kim, David C. Ackley, Jerry K. Holbert, Scott W. Mittelstadt, Martin E. Dowty, C

Journal:

Bioorganic & Medicinal Chemistry

Année:

2007

Langue:

english

Fichier:

PDF, 349 KB

english, 2007

7

Novel pyrazolopiperazinone- and pyrrolopiperazinone-based MCH-R1 antagonists

Kenneth M. Meyers, José Méndez-Andino, Anny-Odile Colson, X. Eric Hu, John A. Wos, Maria C. Mitchell, Karen Hodge, Jeremy Howard, Jennifer L. Paris, Martin E. Dowty, Cindy M. Obringer, Ofer Reizes

Journal:

Bioorganic & Medicinal Chemistry Letters

Année:

2007

Langue:

english

Fichier:

PDF, 213 KB

english, 2007

8

Anti-inflammatory activity and neutrophil reductions mediated by the JAK1/JAK3 inhibitor, CP-690,550, in rat adjuvant-induced arthritis

Debra M Meyer, Michael I Jesson, Xiong Li, Mollisa M Elrick, Christie L Funckes-Shippy, James D Warner, Cindy J Gross, Martin E Dowty, Shashi K Ramaiah, Jeffrey L Hirsch, Matthew J Saabye, Jennifer L

Journal:

Journal of Inflammation

Année:

2010

Langue:

english

Fichier:

PDF, 821 KB

english, 2010

9

The Next Generation of MMP Inhibitors: Design and Synthesis

BISWANATH DE, MICHAEL G. NATCHUS, MENYAN CHENG, STANISLAW PIKUL, NEIL G. ALMSTEAD, YETUNDE O. TAIWO, CATHERINE E. SNIDER, LONGYIN CHEN, BOBBY BARNETT, FEI GU, MARTIN DOWTY

Journal:

Annals of the New York Academy of Sciences

Année:

1999

Langue:

english

Fichier:

PDF, 711 KB

english, 1999

10

Improved Prediction of In Vivo Peroral Absorption from In Vitro Intestinal Permeability Using an Internal Standard to Control for Intra- and Inter-Rat Variability

Martin E. Dowty, Charles R. Dietsch

Journal:

Pharmaceutical Research

Année:

1997

Fichier:

PDF, 464 KB

1997

11

Transport of Thyrotropin Releasing Hormone in Rabbit Buccal Mucosain Vitro

Martin E. Dowty, Kim E. Knuth, Brian K. Irons, Joseph R. Robinson

Journal:

Pharmaceutical Research

Année:

1992

Fichier:

PDF, 4.25 MB

1992

12

Effect of extracellular pH on cytoplasmic pH and mechanism of pH regulation in cultured bovine corneal endothelium: Possible importance in drug transport studies

Martin E. Dowty, Pierre Braquet

Journal:

International Journal of Pharmaceutics

Année:

1991

Langue:

english

Fichier:

PDF, 566 KB

english, 1991

13

Reversed-Phase High-Performance Liquid Chromatographic Analysis of Oligoglycines (One to Six Amino Acid Residues)

Ian G. Tucker, Martin E. Dowty, Michel Veillard, Mark A. Longer, Joseph R. Robinson

Journal:

Pharmaceutical Research

Année:

1989

Fichier:

PDF, 353 KB

1989

14

Lack of effect of tofacitinib (CP-690,550) on the pharmacokinetics of the CYP3A4 substrate midazolam in healthy volunteers: confirmation of in vitro data

Pankaj Gupta, Christine Alvey, Rong Wang, Martin E. Dowty, Odette A. Fahmi, Robert L. Walsky, Richard J. Riese, Sriram Krishnaswami

Journal:

British Journal of Clinical Pharmacology

Année:

2012

Langue:

english

Fichier:

PDF, 927 KB

english, 2012

15

How Current Understanding of Clearance Mechanisms and Pharmacodynamics of Therapeutic Proteins Can Be Applied for Evaluation of Their Drug-Drug Interaction Potential

Kraynov, E., Martin, S. W., Hurst, S., Fahmi, O. A., Dowty, M., Cronenberger, C., Loi, C.-M., Kuang, B., Fields, O., Fountain, S.

Journal:

Drug Metabolism and Disposition

Année:

2011

Langue:

english

Fichier:

PDF, 502 KB

english, 2011

16

Major-element vapor fractionation on the lunar surface: An unusual lithic fragment from the Luna 20 fines

Eric Dowty, Klaus Keil, Martin Prinz

Journal:

Earth and Planetary Science Letters

Année:

1973

Langue:

english

Fichier:

PDF, 616 KB

english, 1973

17

Ferroan anorthosite: A widespread and distinctive lunar rock type

Eric Dowty, Martin Prinz, Klaus Keil

Journal:

Earth and Planetary Science Letters

Année:

1974

Langue:

english

Fichier:

PDF, 1.78 MB

english, 1974

18

Approach for extrapolating in vitro metabolism data to refine bioconcentration factor estimates

Christina E. Cowan-Ellsberry, Scott D. Dyer, Susan Erhardt, Mary Jo Bernhard, Amy L. Roe, Martin E. Dowty, Annie V. Weisbrod

Journal:

Année:

2008

Langue:

english

Fichier:

PDF, 239 KB

english, 2008

19

Design, Synthesis, and Evaluation of Proline and Pyrrolidine Based Melanocortin Receptor Agonists. A Conformationally Restricted Dipeptide Mimic Approach

Tian, Xinrong, Field, Timothy B., Switzer, Adrian G., Mazur, Adam W., Ebetino, Frank H., Wos, John A., Berberich, Steve M., Jayasinghe, Lalith R., Obringer, Cindy M., Dowty, Martin E., Pinney, Beth B.

Journal:

Journal of Medicinal Chemistry

Année:

2006

Langue:

english

Fichier:

PDF, 303 KB

english, 2006

20

Oxide minerals in lithic fragments from Luna 20 fines

Robin Brett, R.C Gooley, Eric Dowty, Martin Prinz, Klaus Keil

Journal:

Geochimica et Cosmochimica Acta

Année:

1973

Langue:

english

Fichier:

PDF, 1.35 MB

english, 1973

21

Design, Synthesis, and Biological Evaluation of Matrix Metalloproteinase Inhibitors Derived from a Modified Proline Scaffold

Cheng, Menyan, De, Biswanath, Almstead, Neil G., Pikul, Stanislaw, Dowty, Martin E., Dietsch, Charles R., Dunaway, C. Michelle, Gu, Fei, Hsieh, Lily C., Janusz, Michael J., Taiwo, Yetunde O., Natchus,

Journal:

Journal of Medicinal Chemistry

Année:

1999

Langue:

english

Fichier:

PDF, 282 KB

english, 1999

22

Development of New Hydroxamate Matrix Metalloproteinase Inhibitors Derived from Functionalized 4-Aminoprolines

Natchus, Michael G., Bookland, Roger G., De, Biswanath, Almstead, Neil G., Pikul, Stanislaw, Janusz, Michael J., Heitmeyer, Sandra A., Hookfin, Erin B., Hsieh, Lily C., Dowty, Martin E., Dietsch, Char

Journal:

Journal of Medicinal Chemistry

Année:

2000

Langue:

english

Fichier:

PDF, 398 KB

english, 2000

23

Evaluation of the potential interaction between tofacitinib and drugs that undergo renal tubular secretion using metformin, an in vivo marker of renal organic cation transporter 2

Klamerus, Karen J., Alvey, Christine, Li, Lei, Feng, Bo, Wang, Rong, Kaplan, Irina, Shi, Haihong, Dowty, Martin E., Krishnaswami, Sriram

Journal:

Clinical Pharmacology in Drug Development

Année:

2014

Langue:

english

Fichier:

PDF, 359 KB

english, 2014

24

A Holistic Strategy for Characterizing the Safety of Metabolites through Drug Discovery and Development

Walker, Don, Brady, Joe, Dalvie, Deepak, Davis, John, Dowty, Martin, Duncan, J. Neil, Nedderman, Angus, Obach, R. Scott, Wright, Pat

Journal:

Chemical Research in Toxicology

Année:

2009

Langue:

english

Fichier:

PDF, 314 KB

english, 2009

25

Plasmid DNA Entry Into Postmitotic Nuclei of Primary Rat Myotubes

Martin E. Dowty, Phillip Williams, Guofeng Zhang, James E. Hagstrom and Jon A. Wolff

Journal:

Proceedings of the National Academy of Sciences

Année:

1995

Langue:

english

Fichier:

PDF, 798 KB

english, 1995

26

Utility of a human FcRn transgenic mouse model in drug discovery for early assessment and prediction of human pharmacokinetics of monoclonal antibodies

Avery, Lindsay B., Wang, Mengmeng, Kavosi, Mania S., Joyce, Alison, Kurz, Jeffrey C., Fan, Yao-Yun, Dowty, Martin E., Zhang, Minlei, Zhang, Yiqun, Cheng, Aili, Hua, Fei, Jones, Hannah M., Neubert, Hen

Journal:

Année:

2016

Langue:

english

Fichier:

PDF, 2.11 MB

english, 2016

27

Animal Models for Evaluation of Drug-Drug Interaction Potential of Biotherapeutics

Kraynov, Eugenia, E. Dowty, Martin, Odette A. Fahmi, Odette, Fields, Owen

Journal:

Current Drug Metabolism

Année:

2012

Langue:

english

Fichier:

PDF, 120 KB

english, 2012

28

Model-informed Development and Registration of a Once-daily Regimen of Extended-release Tofacitinib

Lamba, Manisha, Hutmacher, Matthew M., Furst, Daniel E., Dikranian, Ara, Dowty, Martin E., Conrado, Daniela, Stock, Thomas, Nduaka, Chudy, Cook, Jack, Krishnaswami, Sriram

Journal:

Clinical Pharmacology & Therapeutics

Année:

2016

Langue:

english

Fichier:

PDF, 793 KB

english, 2016

29

The Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of a TYK2/JAK1 Inhibitor (PF-06700841) in Healthy Subjects and Patients With Plaque Psoriasis

Banfield, Christopher, Scaramozza, Matthew, Zhang, Weidong, Kieras, Elizabeth, Page, Karen M., Fensome, Andrew, Vincent, Michael, Dowty, Martin E., Goteti, Kosalaram, Winkle, Peter J., Peeva, Elena

Journal:

Journal of Clinical Pharmacology

Année:

2017

Langue:

english

Fichier:

PDF, 632 KB

english, 2017

30

LC–MS/MS assay for N 1 -methylnicotinamide in humans, an endogenous probe for renal transporters

Luo, Lina, Kay, Jared, Zhang, Jenny, Holliman, Christopher L, Rodrigues, A David, Dowty, Martin, Banfield, Christopher, Ramanathan, Ragu

Journal:

Année:

2018

Langue:

english

Fichier:

PDF, 984 KB

english, 2018

31

Dual Inhibition of TYK2 and JAK1 for the Treatment of Autoimmune Diseases: Discovery of (( S )-2,2-Difluorocyclopropyl)((1 R ,5 S )-3-(2-((1-methyl-1 H -pyrazol-4-yl)amino)pyrimidin-4-yl)-3,8-diazabicyclo[3.2.1]octan-8-yl)methanone (PF-06700841)

Fensome, Andrew, Ambler, Catherine M., Arnold, Eric, Banker, Mary Ellen, Brown, Matthew F., Chrencik, Jill, Clark, James D., Dowty, Martin E., Efremov, Ivan V., Flick, Andrew, Gerstenberger, Brian S.,

Journal:

Journal of Medicinal Chemistry

Année:

2018

Langue:

english

Fichier:

PDF, 6.36 MB

english, 2018

32

Janus kinase inhibitors for the treatment of rheumatoid arthritis demonstrate similar profiles of in vitro cytokine receptor inhibition

Dowty, Martin E., Lin, Tsung H., Jesson, Michael I., Hegen, Martin, Martin, David A., Katkade, Vaibhav, Menon, Sujatha, Telliez, Jean‐Baptiste

Journal:

Pharmacology Research & Perspectives

Année:

2019

Langue:

english

Fichier:

PDF, 1.82 MB

english, 2019

33

Janus kinase inhibitors for the treatment of rheumatoid arthritis demonstrate similar profiles of in vitro cytokine receptor inhibition

Dowty, Martin E., Lin, Tsung H., Jesson, Michael I., Hegen, Martin, Martin, David A., Katkade, Vaibhav, Menon, Sujatha, Telliez, Jean‐Baptiste

Journal:

Pharmacology Research & Perspectives

Année:

2019

Fichier:

PDF, 1.82 MB

2019

34

Design and optimization of a series of 4-(3-azabicyclo[3.1.0]hexan-3-yl)pyrimidin-2-amines: Dual inhibitors of TYK2 and JAK1

Fensome, Andrew, Ambler, Catherine M., Arnold, Eric, Banker, Mary Ellen, Clark, James D., Dowty, Martin E., Efremov, Ivan V., Flick, Andrew, Gerstenberger, Brian S., Gifford, Roger S., Gopalsamy, Aria

Journal:

Bioorganic & Medicinal Chemistry

Année:

2020

Fichier:

PDF, 3.62 MB

2020

35

Demonstration of In Vitro to In Vivo Translation of a TYK2 Inhibitor That Shows Cross Species Potency Differences

Gerstenberger, Brian S., Banker, Mary Ellen, Clark, James D., Dowty, Martin E., Fensome, Andrew, Gifford, Roger, Griffor, Matthew C., Hegen, Martin, Hollingshead, Brett D., Knafels, John D., Lin, Tsun

Journal:

Scientific Reports

Année:

2020

Fichier:

PDF, 1.92 MB

2020

36

Application of Physiologically Based Pharmacokinetic Modeling to Predict Drug Exposure and Support Dosing Recommendations for Potential DrugâDrug Interactions or in Special Populations: An Example Using Tofacitinib

Tse, Susanna, Dowty, Martin E., Menon, Sujatha, Gupta, Pankaj, Krishnaswami, Sriram

Journal:

Journal of Clinical Pharmacology

Année:

2020

Fichier:

PDF, 280 KB

2020

37

P190 - The effect of CYP2C9 and CYP2C19 genotype on the pharmacokinetics of PF 04965842, A JAK1 inhibitor in clinical development

Dowty, Martin, Yang, Xin, Lin, Jian, Bauman, Jonathan, Doran, Angela, Goosen, Theunis, Wood, Linda, Johnson, Jillian, Banfield, Christopher, Gupta, Pankaj, Malhotra, Bimal

Journal:

Drug Metabolism and Pharmacokinetics

Année:

2020

Fichier:

PDF, 46 KB

2020

38

Discovery of Tyrosine Kinase 2 (TYK2) Inhibitor (PF-06826647) for the Treatment of Autoimmune Diseases

Gerstenberger, Brian S, Ambler, Catherine M., Arnold, Eric P, Banker, Mary Ellen, Brown, Matthew F., Clark, James D, Dermenci, Alpay, Dowty, Martin E., Fensome, Andrew, Fish, Susan, Hayward, Matthew M

Journal:

Journal of Medicinal Chemistry

Année:

2020

Fichier:

PDF, 885 KB

2020

39

15433 Assessment of cytochrome P450 3A inhibition and induction of abrocitinib: Midazolam drug-drug interaction (DDI) study and oral contraceptive DDI study

Wang, Xiaoxing, Huh, Yeamin, Curto, Madelyn, Chan, Gary, Dowty, Martin E., O'Gorman, Melissa, Tripathy, Sakambari, Malhotra, Bimal, Gupta, Pankaj

Journal:

Journal of the American Academy of Dermatology

Année:

2020

Fichier:

PDF, 147 KB

2020